Mature b cell

Your browser does not have JavaScript enabled and some parts of this website will not work without it. For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome. B cells are mediators of the humoral response, or antibody-mediated immunity. By studying this particular cell group we learn more about the inner workings of the immune system, which consequently increases our awareness of the possible causes behind a variety of autoimmune disorders and cancers. Broad immunological research unlocks valuable insight of what future steps might be taken to treat these pathologies. Generation of the B cell begins in the bone marrow where stem cells give rise to lymphoid cells.
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B Cells: Antibody Producing Immune Cells

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B cells immunophenotyping | Abcam

These are types of lymphoma that affect B lymphocytes. The most common types of B-cell lymphomas are listed below. This is the most common type of NHL in the United States, accounting for about 1 out of every 3 lymphomas. The lymphoma cells look fairly large when seen with a microscope.
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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

B probably from b ursa-derived produced by the bursa of Fabricius. See more words from the same year. Accessed 9 Aug. More Definitions for B cell.
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Lineage commitment and differentiation to a mature cell type are considered to be unidirectional and irreversible processes under physiological conditions. The commitment of haematopoietic progenitors to the B-cell lineage and their development to mature B lymphocytes critically depend on the transcription factor encoded by the paired box gene 5 Pax5. Here we show that conditional Pax5 deletion in mice allowed mature B cells from peripheral lymphoid organs to dedifferentiate in vivo back to early uncommitted progenitors in the bone marrow, which rescued T lymphopoiesis in the thymus of T-cell-deficient mice.
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