Useful for skin and skin structure infections when some Gram - and anaerobic coverage is also desirable bite, mixed abscess. Not recommended for S. A practical alternative for S. A good choice for skin and skin structure infections due to S.
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Vancomycin - Infectious Diseases - Merck Manuals Professional Edition
Methicillin-resistant Staphylococcus aureus MRSA is one of the leading causes of both health care— and community-acquired infections. This seems to be acquired in the outpatient setting, and transmission is through close physical contact such as in day care centers, Indian reservations, and correctional facilities and among athletes, military personnel, and men who have sex with men. CA-MRSA strains are more likely to encode certain virulent factors that have been associated with severe pneumonia especially in children and skin and soft tissue infections in adults. To be considered CA-MRSA, the patient must not have any of the following: recent hospitalization; admission to a nursing home, hospice, or skilled nursing facility; dialysis; or recent surgery. The patient must also not have any indwelling catheters or other medical devices.
Vancomycin pulmonary penetration
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Approximately 20 percent of healthy persons are persistent carriers of Staphylococcus aureus , and 60 percent are intermittent carriers. Colonization rates are increased in hemodialysis patients, illicit injection drug users, surgical patients, and patients with insulin-dependent or poorly controlled diabetes. Hospitalized patients with S. Community-acquired MRSA infections, which usually cause skin and soft-tissue infections, have become more common.
