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ABS Biochemistry 2. The development of new scientific ways to see more deeply into the building blocks of nature on a cellular level has led to the some of the greatest advances in medicine over the last century. Now, new research into phosphoinositides, which are a family of membrane lipids essential for many biological and pathological processes and which represent one of the most functionally versatile membrane lipid families involved in human health and disease, has seen further developments in the use of mass spectrometry in continuing to push back the barriers leading to new treatments for many diseases. In the past, due to various reasons related to their complexity and their low intracellular concentrations, the profiling of these lipids and the linking of a specific acyl variant to biological change has been difficult. However, a new system called PRMC-MS Phosphoinositide Regioisomer Measurement by Chiral column chromatography and Mass Spectrometry has now enabled the characterization of the dynamics of phosphoinositide acyl variants both in intracellular and extracellular environments.

Time travel has always captured the popular imagination. According to Professor Hawking, observations of the Universe have shown that it is not sufficiently warped, leaving only the third possibility valid — wormholes. Wormholes connect distant regions in a region in space-time which has a negative curvature, which can be kept open using matter with negative energy density. Some have theorised that wormholes are linked by a concept known as quantum entanglement, where particles have linked behaviour even at great distances.

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